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عمومی::
نشانهها و علائم
Hence, persisting symptoms and signs of fatigue that are not relieved by sleep or physical rest may be an indication of a serious medical problem.
Symptoms and signs of CrF can appear at any time during the course of cancer [28], including:
For example, if symptoms and signs of fatigue last for an extended period of time without a defined cause, and if other defined criteria are present, the patient should be diagnosed with CFS [3, 4].
� non-specificity symptoms and signs of CrF, as they may also be due to other diseases or functional impairments
;As such, the use of ESAs should not be based on a target hemoglobin value, but rather on the symptoms and signs of anemia and their impact on physical functioning and other measures of quality of life [20].
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